-Collagen implants can increase the efficacy of trabeculectomy without the need for antifibrotic agents like mitomycin C.
MOA:
-Ologen is composed of 3-D collagen–glycosaminoglycan copolymers, which form a porous structure.
- Instead of using antifibrotic agents, the porous structure provides a scaffold for fibroblasts to grow randomly, which could reduce scar formation effectively.
- The collagen matrix itself can function like a reservoir to absorb the aqueous humor.
- Provides pressure on the scleral flap to create controlled drainage in the subconjunctival space.
ADVANTAGE:
- Helps to limit hypotony through a tamponading effect over the scleral flap.
- Modulates wound healing without producing thin, avascular blebs.
- Decreased surgical time.
- No special handling precautions.
- Not a teratogen like MMC.
DISADVANTAGES:
-Thinner implant can be more difficult to place.
-Expensive.
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