𝘖𝘤𝘶𝘭𝘢𝘳 𝘚𝘶𝘳𝘧𝘢𝘤𝘦 𝘚𝘲𝘶𝘢𝘮𝘰𝘶𝘴 𝘕𝘦𝘰𝘱𝘭𝘢𝘴𝘪𝘢 (𝘖𝘚𝘚𝘕)
Describes the entire spectrum of squamous neoplastic disease from dysplasia to carcinoma in situ and invasive SCC
𝐓𝐡𝐫𝐞𝐞 𝐠𝐫𝐚𝐝𝐞𝐬 (𝐋𝐞𝐞 𝐚𝐧𝐝 𝐇𝐢𝐫𝐬𝐭): 1) Benign Dysplasia Papilloma Pseudoepitheliomatous hyperplasia Benign hereditary intraepithelial dyskeratosis 2) Preinvasive OSSN Conjunctival/corneal carcinoma in situ 3) Invasive OSSN Squamous carcinoma Mucoepidermoid carcinoma 𝐄𝐭𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐟𝐚𝐜𝐭𝐨𝐫𝐬: ● Old age ● Ultraviolet B radiation ● Males ● HPV infection ● HIV ● Xeroderma pigmentosum ● Chemical exposure ● Cigarette smoking ● Vitamin A deficiency 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐅𝐞𝐚𝐭𝐮𝐫𝐞𝐬: ● Most commonly in the interpalpebral area near the limbus ● Can extend across limbus to involve cornea ● Flat/Raised, pearly-gray or pink well-demarcated mass with feeder vessels ● Fluorescein/lissamine/rose bengal stain used to highlight the lesion 𝐌𝐨𝐫𝐩𝐡𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐓𝐲𝐩𝐞𝐬: 1. 𝘗𝘭𝘢𝘤𝘰𝘪𝘥 -Gelatinous : Commonest, placoid lesion with shiny velvety surface, and tufted vessels -Papilliform -Velvety -Leukoplakic 2. 𝘕𝘰𝘥𝘶𝘭𝘢𝘳: Well circumscribed elevated focal mass with mulberry appearance 3. 𝘋𝘪𝘧𝘧𝘶𝘴𝘦 variant: Shows radial growth pattern without well defined margin and may mimic chronic blepharoconjunctivitis Corneal involvement in OSSN gives a ground glass appearance with well defined borders or a beaten metal appearance on retroillumination 𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐢𝐬: ● Histopathology ● Impression Cytology ● AS OCT ● Confocal Microscopy 𝐌𝐚𝐧𝐚𝐠𝐞𝐦𝐞𝐧𝐭: ● Surgical excision with wide margins and edge cryotherapy ● Chemotherapy (MMC/5FU) ● Radiotherapy (Ruthenium-106) ● Immunotherapy with Interferon alpha 2b www.ophthalmobytes.com Image from Rajan Eye Care Hospital #ophthalmology #ophthal #doctor #health #medical #vision #education #optometry #medicalstudent #optometrist #medicine #eye #ophtho #ophthalmologist #ophthalmo #med #medicaleducation #ophthalmologyresident #ophthalmologyresidency #ossn #ocularsurfacesquamousneoplasia