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Cloudy Corneas!

๐˜Š๐˜ฐ๐˜ฏ๐˜จ๐˜ฆ๐˜ฏ๐˜ช๐˜ต๐˜ข๐˜ญ ๐˜๐˜ฆ๐˜ณ๐˜ฆ๐˜ฅ๐˜ช๐˜ต๐˜ข๐˜ณ๐˜บ ๐˜Œ๐˜ฏ๐˜ฅ๐˜ฐ๐˜ต๐˜ฉ๐˜ฆ๐˜ญ๐˜ช๐˜ข๐˜ญ ๐˜‹๐˜บ๐˜ด๐˜ต๐˜ณ๐˜ฐ๐˜ฑ๐˜ฉ๐˜บ (๐˜Š๐˜๐˜Œ๐˜‹)โฃ โฃ โ— Bilateral cloudy cornea at birth/perinatallyโฃ โฃ โ— Earlier classified as CHED 1 (AD) and CHED 2 (AR) - now CHED 1 has been eliminated by the International Classification of Corneal Dystrophies (IC3D)โฃ โฃ โ— Chromosome 20p13 - SLCA411 gene - transmembrane protein from bicarbonate transporters family - works as a pump on the stromal side of endothelial cellsโฃ โฃ โ— Degeneration of endothelial cells โ†’ build up of fluid in corneal stromaโฃ โฃ โ— Harboyan syndrome - sensorineural hearing loss with corneal opacification associated with SLCA411 mutationโฃ



โฃ ๐’๐ข๐ ๐ง๐ฌ:โฃ โฃ โ— Reduced vision โ†’ amblyopiaโฃ โ— Nystagmusโฃ โฃ ๐…๐ข๐ง๐๐ข๐ง๐ ๐ฌ:โฃ โฃ โ— Diffuse corneal edema and corneal thickeningโฃ โ— Thickening of Descemetโ€™s membraneโฃ โ— Blue gray ground glass appearance to total corneal opacificationโฃ โฃ Important to differentiate CHED from Congenital glaucomaโฃ โฃ ๐˜š๐˜ถ๐˜ณ๐˜จ๐˜ช๐˜ค๐˜ข๐˜ญ ๐˜ฎ๐˜ข๐˜ฏ๐˜ข๐˜จ๐˜ฆ๐˜ฎ๐˜ฆ๐˜ฏ๐˜ต - Penetrating Keratoplasty / Endothelial Keratoplastyโฃ โฃ www.ophthalmobytes.comโฃ โฃ Image from Rajan Eye Care Hospital #ophthalmology #ophthal #cornea #cornealdystrophy #CHED #doctor #health #medical #vision #education #optometry #medicalstudent #optometrist #medicine #eye #ophtho #ophthalmologist #ophthalmo #med #medicaleducation #ophthalmologyresident #ophthalmologyresidency#ophthalmologyresidency

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