Cancer of the Eye!

Cornea & Ocular SurfaceSystemic Ophthalmology
Written By Madhuvanthi Mohan

๐˜–๐˜ค๐˜ถ๐˜ญ๐˜ข๐˜ณ ๐˜š๐˜ถ๐˜ณ๐˜ง๐˜ข๐˜ค๐˜ฆ ๐˜š๐˜ฒ๐˜ถ๐˜ข๐˜ฎ๐˜ฐ๐˜ถ๐˜ด ๐˜•๐˜ฆ๐˜ฐ๐˜ฑ๐˜ญ๐˜ข๐˜ด๐˜ช๐˜ข (๐˜–๐˜š๐˜š๐˜•)โฃ โฃ

Describes the entire spectrum of squamous neoplastic disease from dysplasia to carcinoma in situ and invasive SCCโฃ

๐“๐ก๐ซ๐ž๐ž ๐ ๐ซ๐š๐๐ž๐ฌ (๐‹๐ž๐ž ๐š๐ง๐ ๐‡๐ข๐ซ๐ฌ๐ญ):โฃ โฃ

1) Benign Dysplasia โฃ

  • Papillomaโฃ

  • Pseudoepitheliomatous hyperplasiaโฃ

  • Benign hereditary intraepithelial dyskeratosisโฃ โฃ

2) Preinvasive OSSN โฃ

  • Conjunctival/corneal carcinoma in situโฃ โฃ

3) Invasive OSSN โฃ

  • Squamous carcinomaโฃ

  • Mucoepidermoid carcinomaโฃ โฃ

๐„๐ญ๐ข๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐Ÿ๐š๐œ๐ญ๐จ๐ซ๐ฌ:โฃ โฃ

โ— Old ageโฃ

โ— Ultraviolet B radiationโฃ

โ— Malesโฃ

โ— HPV infectionโฃ

โ— HIVโฃ

โ— Xeroderma pigmentosumโฃ

โ— Chemical exposureโฃ

โ— Cigarette smokingโฃ

โ— Vitamin A deficiencyโฃ โฃ

๐‚๐ฅ๐ข๐ง๐ข๐œ๐š๐ฅ ๐…๐ž๐š๐ญ๐ฎ๐ซ๐ž๐ฌ:โฃ โฃ

โ— Most commonly in the interpalpebral area near the limbusโฃ

โ— Can extend across limbus to involve corneaโฃ

โ— Flat/Raised, pearly-gray or pink well-demarcated mass with feeder vesselsโฃ

โ— Fluorescein/lissamine/rose bengal stain used to highlight the lesionโฃ โฃ

๐Œ๐จ๐ซ๐ฉ๐ก๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐“๐ฒ๐ฉ๐ž๐ฌ:โฃ โฃ

1. ๐˜—๐˜ญ๐˜ข๐˜ค๐˜ฐ๐˜ช๐˜ฅโฃ

-Gelatinous : Commonest, placoid lesion with shiny velvety surface, and tufted vesselsโฃ

-Papilliformโฃ -Velvetyโฃ

-Leukoplakicโฃ โฃ

2. ๐˜•๐˜ฐ๐˜ฅ๐˜ถ๐˜ญ๐˜ข๐˜ณ:

Well circumscribed elevated focal mass with mulberry appearanceโฃ โฃ

3. ๐˜‹๐˜ช๐˜ง๐˜ง๐˜ถ๐˜ด๐˜ฆ variant:

Shows radial growth pattern without well defined margin and may mimic chronic blepharoconjunctivitisโฃ โฃ

Corneal involvement in OSSN gives a ground glass appearance with well defined borders or a beaten metal appearance on retroilluminationโฃ โฃ

๐ƒ๐ข๐š๐ ๐ง๐จ๐ฌ๐ข๐ฌ:โฃ โฃ

โ— Histopathologyโฃ

โ— Impression Cytology โฃ

โ— AS OCTโฃ

โ— Confocal Microscopyโฃ โฃ

๐Œ๐š๐ง๐š๐ ๐ž๐ฆ๐ž๐ง๐ญ:โฃ โฃ

โ— Surgical excision with wide margins and edge cryotherapyโฃ

โ— Chemotherapy (MMC/5FU)โฃ

โ— Radiotherapy (Ruthenium-106)โฃ

โ— Immunotherapy with Interferon alpha 2bโฃ

โฃ www.ophthalmobytes.comโฃ โฃ

Image from Rajan Eye Care Hospital

#ophthalmology #ophthal #doctor #health #medical #vision #education #optometry #medicalstudent #optometrist #medicine #eye #ophtho #ophthalmologist #ophthalmo #med #medicaleducation #ophthalmologyresident #ophthalmologyresidency #ossn #ocularsurfacesquamousneoplasia #cornea #ocularsurface #systemicophthalmology

Madhuvanthi Mohan
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